Understanding CBD Crystal Isolate vs CBD Paste or Oils
Some things to consider before making the right choice for you or your loved ones:
We would like to make some points clear about our products so that you can make a more informed decision when choosing what's right for you, a lot of people see the high percentage of a Crystal and assume it’s better, you see 99.7% and you say to yourself, “hm...It’s got to be the best", Well, I don’t blame you. But that’s not really the case, and here's why: Crystals are an isolate of CBD, meaning - it’s just pure Cannabidiol. When you buy a Paste, or Oil, it has CBD, yes, but it has other important compounds which give it taste, smell, flavor, (the way it smells like cannabis) ahhh - so sweet! The full range of compounds found in Paste or Oils all work together, they all play an important role in how these compounds affect the body, The compounds found in Paste or Oil's which give it these characteristics are known as flavonoids, terpenes, and THC. Any product with the full range of compounds will ALWAYS be far more effective than any CBD Crystal can ever be, when I decided to offer crystals, it was really geared more towards people who CANNOT consume THC, people with city jobs, or people who get tested for various reasons. Crystals are also popular for Vape Oil manufacturers and Dabbers because they're easy to dissolve or smoke... One other side note when shopping, when you see someone offering a CBD Oil that’s clear - you can be sure it’s just an Isolate product.
In conclusion: If you can consume THC, Buy a Paste or Oil. Yes - we are in business to sell product, but I want Our clients to be getting the most for their money, the most bang for their buck, and most importantly the most effective options to treat whatever they are hoping to treat.
PLEASE READ BELOW TO FURTHER EDUCATE YOURSELF ON CBD OIL
1. What is cannabidiol (CBD)? What is CBD oil?
Cannabidiol (CBD) is a naturally occurring constituent of industrial hemp/cannabis. Its formula is C21H30O2 and it has a molecular mass of 314.4636. It is the most abundant non-psychoactive cannabinoid found in cannabis, and is being scientifically investigated for various reasons.
‘CBD oil’ is a cannabis oil (whether derived from marijuana or industrial hemp, as the word cannabis is the Latin genus name for both) that has significant amounts of cannabidiol (CBD) contained within it.
Our CBD oils are derived from industrial hemp, so they could be considered CBD-rich hemp oil, hemp derived CBD oil, or CBD-rich cannabis oil. Again, cannabis doesn’t mean marijuana, but is the genus name, and general umbrella term which all forms of marijuana and hemp fall under. The form of cannabis we use for Our CBD oils is industrial hemp; we do not sell marijuana.
2. If a CBD hemp extract is 50% CBD, what’s the other 50%? What’s in CBD Oil besides cannabidiol (CBD)?
Our CBD oils contain over 80 different phyto-cannabinoids, most notably cannabidiol (CBD), CBC, CBG, CBN, and probably others yet to be adequately identified. In addition to the cannabinoids present in Our industrial hemp oil extracts, there are also many other types of natural molecules and phyto-chemical compounds such as amino acids, carbohydrates, vitamins (including B1, B2, B6, D, & E), fatty acids (including omega 3 & 6), trace minerals (including iron, zinc, calcium, magnesium, & potassium), carotene, chlorophyll, flavonoids, ketones, nitrogenous compounds, alkanes, alcohols, glycosides, pigments, hemp seed oil, water, and terpenes. The most common terpenes in Our CBD oils are Ourrcene, Beta-caryophyllene, Terpinolene, Linalool, alpha-Pinene, beta-Pinene, Nerolidol OG Phytol, trans-alpha-Bergamotene, Limonene/beta-Phellandrene (Co-elution), alpha-Humulene, (E)-beta-Farnesene, and delta-3-Carene.
3. How does CBD oil work?
Cannabidiol (CBD), a non-psychoactive component of the marijuana plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. CBD acts through various receptor-independent channels and by binding with a number of non-cannabinoid receptors and ion channels.
Here are some of the ways that CBD confers its therapeutic effects.
CBD and FAAH
Unlike psychoactive THC, CBD has little binding affinity to either the CB1 or CB2 cannabinoid receptors. Instead, CBD indirectly stimulates endogenous cannabinoid signaling by suppressing the enzyme fatty acid amide hydroxylase (FAAH)—the enzyme that breaks down anandamide, the first endocannabinoid discovered in the mammalian brain in 1992.
Whereas the cannabinoid molecules found in cannabis are considered “exogenous ligands” to the cannabinoid (CB) receptor family, anandamide is an “endogenous” cannabinoid ligand—meaning it binds to one or more cannabinoid receptors and is found naturally inside the mammalian brain and body. Anandamide favors the CB1 receptor, which is concentrated in the brain and central nervous system. Because FAAH is involved in the metabolic breakdown of anandamide, less FAAH means more anandamide remains present in the body for a longer duration. More anandamide means greater CB1 activation.
CBD enhances endocannabinoid tone by supressing FAAH.
By inhibiting the enzyme that metabolizes and degrades anandamide, CBD enhances the body’s innate protective endocannabinoid response. At the same time, CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC.
CBD also stimulates the release of 2-AG, another endocannabinoid that activates both CB1 and CB2 receptor. CB2 receptors are predominant in the peripheral nervous system and the immune system.
The Vanilloid Receptor
While CBD has little binding affinity for either of the two cannabinoid receptors, it has been shown to directly interact with other “G-protein-coupled” receptors and ion channels to confer a therapeutic effect. CBD, for example, binds to the TRPV-1 receptor, which is known to mediate pain perception, inflammation and body temperature.
TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” There are several dozen TRP receptor variants or subfamilies that mediate the effects of a wide range of medicinal herbs.
Scientists also refer to TRPV-1 as the “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.
CBD is a TRPV-1 “agonist” or stimulant. This is likely one of the reasons why CBD-rich cannabis is an effective treatment for neuropathic pain.
Capsaicin—the pungent compound in hot chili peppers—activates the TRVP-1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV-1 agonist.
The Serotonin Receptor
Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and at the King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety.
At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-depressant effect. This receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.
5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages to produce either an excitatory or inhibitory response, depending on the chemical context of the message.
CBD triggers an inhibitory response that slows down 5-HT1A signaling. In comparison, LSD, mescaline, magic mushrooms, and several other hallucinogenic drugs activate a different type of 5-HT receptor that produces an excitatory response.
The Adenosine Receptor
CBD’s anxiolytic (anti-anxiety) properties may in part be attributable to its activation of the adenosine receptor. Adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. The adenosine (A2A) receptor has broad anti-inflammatory effects throughout the body.
Adenosine receptors also play a significant role in the brain. They down-regulate the release of other neurotransmitters such as dopamine and glutamate.
Whereas cannabidiol activates the TRPV-1 vanilloid receptor, the A2A adenosine receptor, and the 5-HT1A serotonin receptor, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.
GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors.
GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.
GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis.
GPR55, when activated, also promotes cancer cell proliferation, according to 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer.
CBD is a GPR55 antagonist, as University of Aberdeen scientist Ruth Ross disclosed at the 2010 conference of the International Cannabinoid Research Society in Lund, Sweden.
By blocking GPR55 signaling, CBD may act to decrease both bone reabsorption and cancer cell proliferation.
CBD also exerts an anti-cancer effect by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell's nucleus. Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines.
PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.
PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics, accordingly, may benefit from a CBD-rich treatment regimen.
CBD’s enzyme-mediated activation of the PPAR-alpha receptor may have antipsychotic effects. Polymorphisms or mutations in the gene encoding PPAR-alpha can result in deficient PPAR-alpha signaling, which has been linked to schizophrenia. PPAR-alpha activation is both anti-inflammatory and can decrease dopamine release, thereby minimizing schizophrenic symptoms.
4. What’s the difference between Hemp and Marijuana?
Scientifically and genetically, industrial Hemp and Marijuana can be the same plant, with a genus and species name of Cannabis Sativa. Industrial Hemp is always a strain of Cannabis sativa, while marijuana can be Cannabis sativa, Cannabis indica, or Cannabis ruderalis. The major difference is how industrial hemp has been bred compared to a marijuana form of Cannabis sativa. Industrial hemp is very fibrous, with long strong stalks, and barely has any flowering buds, while a marijuana strain of Cannabis sativa will be smaller, bushier, and full of flowering buds. Marijuana, 99% of the time, has a high amount of THC and only a very low amount of CBD. Hemp, on the other hand, naturally has a very high amount of CBD, and naturally has a low, trace amount of THC. Fortunately, the cannabinoid profile of hemp is ideal for people looking for benefits from cannabis without the ‘high.’
Hemp is used for making medicinal remedies, food, fiber, rope, paper, bricks, oil, natural plastic, and so much more. Whereas marijuana is usually used just recreationally, spiritually, and medicinally.
*Our hemp derived, CBD oil blends are sometimes referred to by people as cannabis oil, as the term cannabis can technically describe hemp or marijuana, and in our case cannabis oil is obviously being used to describe our hemp oils.
5. Is CBD from Hemp as good as CBD from marijuana?
The short answer is yes. CBD is CBD, whether from marijuana or hemp. Most marijuana has a very low cannabidiol profile, so most of the time hemp would be much more preferable regarding CBD potency because it naturally has such a high amount of it.
There are however certain strains of marijuana that are being grown with a very high CBD content, but this is presently very rare. And the few growers that do have high CBD marijuana strains are struggling to provide for all the people in need. Our CBD percentage from hemp is still comparable to these high CBD marijuana strains, and will soon actually surpass them. So, industrial hemp is not just an ideal alternative to marijuana, but is most of the time the preferable choice.
*The cannabis strain Charolotte’s Web is now considered a variety of hemp, which flies in the face of a common misconception that marijuana is a better source of CBD than hemp, being that Charlotte’s Web gave CBD the very popularity it is now experiencing. THC and CBD tend to balance each other out, ratio-wise, in cannabis plants, so if enough breeding attention is given to increasing CBD levels, the THC levels will naturally fall and eventually you will have a harvest that will be under .3% THC on a dry-weight basis, making it fall within the definition of Industrial Hemp. Hemp is truly a wonderful source of cannabidiol (CBD), as is obvious from Our quality and the feedback we’ve received from thousands of different people.
6. Is your CBD Oil similar Charlotte’s Web CBD Oil?
Yes, they are similar, but there are slight differences. Just like Charlotte’s Web, the cannabis strains we use to produce Our CBD oils are considered industrial hemp, a classification of Cannabis sativa with only trace amounts of THC (the main psychoactive component in the cannabis genus). However, Our hemp cultivars are EU-certified, whereas Charlotte’s Web is not. We use multiple hemp cultivars for Our products; Charlotte’s Web is just one of about 50 different strains of industrial hemp, all with low THC levels and high CBD levels. As with all natural products (think grapes and wine), with Hemp and CBD oil there are natural variances in odor, flavor, appearance, yield, etc., that are effected by the cultivar, year, location, month of harvest, elevation level, soil type, etc.. Examples of components in hemp that may vary batch to batch, year to year, include fatty acid content, vitamin content, mineral content, cannabinoid profile, terpene profile, amino acid profile, and more. So although the CBD levels are extremely similar, there will be other, maybe less important variances between Charlotte’s Web and the EU-certified strains we use.
Another point of interest is that all Our CBD extracts are produced through subcritical and supercritical CO2 extraction processes, whereas with Charlotte’s Web CBD oil it’s hard to determine what method of extraction is being used, as it’s not mentioned very clearly anywhere it’s sold. The Stanley Brothers have mentioned using a rotary evaporator, which indicates they are using a solvent, but which one is not mentioned anywhere that we looked. On the other hand, we only use CO2 for Our extractions, a natural compound which is generally recognized as safe (GRAS) by the FDA. CO2 extraction is widely regarded as the safest and most efficient method for extracting any botanical substance, including hemp. As it stands, we and most others have no idea how Charlotte’s Web CBD oil is really produced.
7. Why don’t you source your Hemp from within the United States?
We sell country-wide and worldwide, so we must abide by the federal and not just state law. Regarding hemp cultivation, the state and federal laws here in the United States are presently contradicting, and to avoid stepping into an ambiguous area of the law, we are only sourcing Our hemp from countries that we know for certain it is legal to do so from. This way we are following both state and federal law and are able to provide CBD to people all around the world.
We hope to be able to one day provide Colorado Hemp CBD all around the country and world, but we can’t do this until and if hemp farming becomes fully legalized at the federal level.
8. What’s the percentage of cannabidiol in your product?
Our percentages of potency vary from product to product and change several times per year with changes to the product line, please see our updates lab results provided for each product to determine.
9. What is the best method of ingestion?
The best method of ingestion will vary from person to person, many of our clients find the most effective option to be sublingually, under the tongue.
10. What’s the ideal serving size for me, and how often should I take it?
The ideal serving size is not known. In one study we looked at, 2mg of cannabidiol (CBD) had similar effects as 200mg CBD. An important factor to acknowledge when considering this question is that most of the studies and research being performed on CBD use an isolated form of synthetic cannabidiol. Our whole plant, hemp derived CBD oil is different- the CBD most likely works in conjunction with the other cannabinoids (CBN, CBC, CBG, etc.), terpenes, vitamins, minerals, omega lipids and other natural phytochemicals present in industrial hemp.
Also worth mentioning is that the weight of the person may play a role in how the CBD effects the body. A 40 pound child most likely won’t need the same amount as a 250 pound man to gain a similar result.
We generally suggest experimentation when figuring out a good serving for you or your loved one. Phytochemical constituents from hemp (like CBD) are considered by most to be relatively safe, and there hasn’t been any major side effects that we’ve ever seen or heard of. What seems to work may vary greatly from person to person.
One last note on this topic is that your body will build up a storage of cannabidiol in the body, which is unlike most chemicals. Unlike alcohol, which is usually absent from the blood stream and body within 24-48 hours after ingestion, cannabidiol is fat soluble and may stay bound to the cells of the body for weeks. This is important to know because after a few weeks of using CBD oil a lesser amount may be required to gain effects similar to the original servings.
11. What is the safety of cannabidiol and your Hemp CBD oil? Are there negative side effects?
Cannabidiol (CBD), and other phytochemical constituents of cannabis are considered to be generally safe. In hemp’s thousands of years of use there has not been one recorded fatality or major illness contributed to its use that we know of.
In high servings some people can experience a slight sedative effect.
In very high servings (upwards of 200mg of CBD per serving) some people experience what’s being labeled as Dysphoria, an unpleasant emotional state. This is incredibly rare though, and has only been mentioned when using abnormally high amounts of CBD.
12. Which of your CBD products should I get (for X, Y, Z)?
Our products are made of only the highest quality CBD avaiable, we are confident that any product you try, you will love, this really comes down to a matter of personal preferrence, would you prefer something more liquified? Or more thick? Let us know and we'll help you choose the right product for you.
13. Why are hemp derived cannabidiol (CBD oil) products so expensive?
Our cannabidiol rich, hemp oil blends (CBD oils) are produced from industrial hemp, and in order for us to legally (through Federal law) acquire and sell the hemp oil, the hemp must be grown outside the United States. So in order for us to get it here and be able to sell it to all fifty states and worldwide, we must import it from out of the country (more specifically, I acquire the hemp oil from multiple European countries), and the importation is very costly.
A supercritical CO2 oil extraction is performed on the stalks and seeds of mature industrial hemp plants, and the resulting hemp oil is analyzed in a laboratory through an HPLC test. Then the raw CO2 extracted hemp oil is shipped to the U.S. and is further refined at a GMP certified facility. The purified hemp oil is then again analyzed for its potency and purity. And then turning this high cbd, hemp oil extract into the final cbd oil blends is another additional process that takes time and resources. We hope to see the cultivation of industrial hemp become fully legal within the United States. There are small steps being taken in this direction, and we are hopeful that process will continue favorably. This would lead to a dramatic decrease in cost for both the manufacturers and consumers of Hemp products, including Hemp CBD oil. With that in mind, I offer the fairest price possible for Our products.
14. Why do people use CBD oil? CBD oil benefits and uses?
There is a wide variety of medicinal value that has been associated with Hemp since beginning of time, for thousands of years, hemp has been used in a number of ways, please take the time to do your own extensive research and learn more about the health benefits.
15. Is a standard hemp seed oil the same as a high CBD content CBD oil?
Absolutely not. Standard hemp oil, which can be found very cheaply at a grocery store, is a much different product than Our Hemp CBD oil. Standard hemp oil is produced by cold pressing the seeds, whereas Our CBD extract is a supercritical CO2 extraction of the hemp plant itself. Regular hemp oil is considered to be a great nutritive food, and may provide benefits for certain ailments, but it only has a trace amount of CBD in it, and it is the CBD that is being so widely recognized and studied for its potentially far reaching abilities. Our CBD is emulsified and extracted into hemp seed oil, but it is the CBD that is undoubtedly the main ingredient that makes Our product stand out.
16. Do I need to move to states that have legalized Marijuana to get CBD oil? Where do you ship your CBD oil?
Many people are under the impression that the only way to acquire cannabidiol oil for themselves or a loved one is to move to Colorado and get on the waiting lists for CBD from dispensaries and such. Many big news outlets are misinformed and are unfortunately spreading this idea, that you can only get CBD in the states where medical marijuana has been legalized. This is simply not the case though. Because Our CBD comes from hemp, and because we acquire it legally from outside the U.S., we can and do ship to all fifty states, and no medical marijuana card is needed.
We ship all around the world too, but we don’t know the CBD/hemp laws of other countries, so it is up to the consumer to know their country’s laws and whether they should be ordering CBD oil there or not. We are not responsible if an international customer orders from us and the product is taken at his or her country’s customs control. We will ship all around the world, but again, it is the responsibility of the customer to know the laws of his or her own country.
17. Is your CBD hemp oil similar to Rick Simpson Hemp Oil?
They are similar, as the hemp oils and potential effects are similar looking and acting. But Our Hemp CBD oil is more highly standardized and will usually have a much higher content of cannabidiol than one produced through the Rick Simpson method. And oils produced through his method will usually have a much higher THC content.
Rick Simpson Hemp Oil is actually more a method of extraction than it is a specific product. People use the Rick Simpson method with hundreds of different strains of marijuana, so the THC and CBD content of the final oil is always varying greatly, depending on the cannabis the consumers are acquiring. Usually what’s used for Rick Simpson oil is a strain with an inferior CBD content (and high THC), because that’s what the vast amount of marijuana is nowadays. And because Our Hemp (not marijuana) is naturally high in cannabidiol (CBD) the CO2 oil extract consistently has a high amount of CBD and only trace amounts of THC.
Our product is always made from industrial hemp, and Rick Simpson Hemp Oil from marijuana, so the differences that were discussed in question #4 apply here as well. Because our CBD hemp oil is highly standardized and the CBD content is always the same high amount, it is much more useful in trying to figure out a proper regimen and serving size.
Both Rick Simpson Hemp Oil and our CBD Hemp Oil are being used for similar reasons, and both are getting similar feedback as to the success stories being reported.
18. Will I get ‘high’?
No. Our CBD oils are all made from industrial hemp, which only has trace amounts of THC, so there is no psychoactive effect from taking our products.
19) Where do you source your hemp/CBD from?
We source our industrial hemp and CBD extracts from locally operated hemp farms all over Europe, including the countries of Denmark, Germany, Austria, and Switzerland and Slovenia.
20) What kind of testing/analysis is performed on your products?
We have a very strict internal quality assurance system, and we have third party laboratories analyze all of our hemp-CBD extracts and our final products for Cannabinoid Potency, Heavy Metals, Bacterial and Microbials, mycotoxins (Fungal), and Pesticides.